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P2X7 receptor antagonist-6

P2X7 receptor antagonist-6 (Compound 2g) is a negative allosteric P2X7 receptor antagonist with an IC50 of 1.31 μM for hP2X7. P2X7 receptor antagonist-6 can be used for cancer, neurodegenerative, inflammatory, and infectious diseases research[1].

Product Specifications

CAS Number

1114621-31-6

UNSPSC

12352005

Target

P2X Receptor

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Smiles

O=C(NC(CC1=CC=C(C=C1)F)CC2=CC=C(C=C2)F)NC3=CC4=C(OCO4)C=C3

Molecular Formula

C23H20F2N2O3

Molecular Weight

410.41

References & Citations

[1]Zuanon M, et al. Identification of New Human P2X7 Antagonists Using Ligand- and Structure-Based Virtual Screening. J Chem Inf Model. 2025 Jul 14;65 (13) :7143-7155.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2X7 Receptor

Frequently Asked Questions

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