N-Deshydroxyethyl Dasatinib-C3-NH2

N-Deshydroxyethyl Dasatinib-C3-NH2 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for LCK (HY-107447) and a PROTAC linker (HY-76667), which recruits E3 ligases. N-Deshydroxyethyl Dasatinib-C3-NH2 can be used for synthesis of PROTAC SJ11646 (HY-175281) [1][2].

Product Specifications

CAS Number

[1430089-58-9]

Product Name Alternative

N-Deshydroxyethyl BMS-354825-C3-NH2

UNSPSC

12352005

Target

Src; Target Protein Ligand-Linker Conjugates

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCN)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl

Molecular Formula

C23H29ClN8OS

Molecular Weight

501.05

References & Citations

[1]Yang JJ, et al. LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia. bioRxiv [Preprint]. 2025 Jul 7:2025.07.03.663042.|[2]Hu J, et al. Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia. Sci Transl Med. 2022 Aug 24;14 (659) :eabo5228.