LO-3-63
LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4DCAF16-dependent degradation of CDK4/6 in cells[1].
Product Specifications
UNSPSC
12352005
Target
CDK; E1/E2/E3 Enzyme
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(/C=C/C(NC5=CC(Cl)=CN=C5)=O)=O)CC4)C=C3)N=C2N1C6CCCC6)N(C)C
Molecular Formula
C32H35ClN10O3
Molecular Weight
643.14
References & Citations
[1]Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS Cent Sci. 2025 Jun 26;11 (7) :1207-1217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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