LO-3-63
LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4DCAF16-dependent degradation of CDK4/6 in cells[1].
Product Specifications
UNSPSC
12352005
Target
CDK; E1/E2/E3 Enzyme
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(/C=C/C(NC5=CC(Cl)=CN=C5)=O)=O)CC4)C=C3)N=C2N1C6CCCC6)N(C)C
Molecular Formula
C32H35ClN10O3
Molecular Weight
643.14
References & Citations
[1]Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS Cent Sci. 2025 Jun 26;11 (7) :1207-1217.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175187/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2104984-01 24 Strip Well
Human Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) High Sensitivity ELISA Kit
Ask
View Details 
MBS2104984-02 48 Well
Human Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) High Sensitivity ELISA Kit
Ask
View Details MBS2104984-03 96 Well
Human Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) High Sensitivity ELISA Kit
Ask
View Details 
MBS2104984-04 5x 96 Well
Human Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) High Sensitivity ELISA Kit
Ask
View Details 
MBS2104984-05 10x 96 Well
Human Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) High Sensitivity ELISA Kit
Ask
View Details 
BNC941138-100 1x 100 µL
WT1 (Wilm's Tumor 1) (WT1/857 + 6F-H2), CF594 conjugate, 0.1mg/mL
Ask
View Details