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LO-3-62

LO-3-62 is a PROTAC-like SMARCA2/4 degrader with a truncated fumaramide handle. LO-3-62 degrades SMARCA2/4 in cells[1].

Product Specifications

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Epigenetic Reader Domain

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O

Molecular Formula

C23H22ClN7O3

Molecular Weight

479.92

References & Citations

[1]Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS Cent Sci. 2025 Jun 26;11 (7) :1207-1217.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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