LO-3-62
LO-3-62 is a PROTAC-like SMARCA2/4 degrader with a truncated fumaramide handle. LO-3-62 degrades SMARCA2/4 in cells[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Epigenetic Reader Domain
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O
Molecular Formula
C23H22ClN7O3
Molecular Weight
479.92
References & Citations
[1]Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS Cent Sci. 2025 Jun 26;11 (7) :1207-1217.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175186/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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