IDO1-IN-27

IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC50 of 0.3951 μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC50: 62 nM) . IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth[1].

Product Specifications

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; Interleukin Related; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O/N=C(C1=NON=C1NCCNC2=CC=CC=C2)\NC3=CC=C(F)C(Br)=C3

Molecular Formula

C17H16BrFN6O2

Molecular Weight

435.25

References & Citations

[1]Qiu X, et al. Design, Synthesis, and Biological Evaluation of Novel Hydroxyamidine Derivatives as Indoleamine 2,3-Dioxygenase 1 Inhibitors. ACS Med Chem Lett. 2025 Jun 30;16 (7) :1401-1409.