LO-3-61
LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras) -like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Epigenetic Reader Domain
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(C(C[C@H]3C4=NN=C(C)N4C5=C(C(C)=C(C)S5)C(C6=CC=C(Cl)C=C6)=N3)=O)CC2)=O
Molecular Formula
C32H30Cl2N8O3S
Molecular Weight
677.60
References & Citations
[1]Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS Cent Sci. 2025 Jun 26;11 (7) :1207-1217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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