Arrestin-3 modulator-1
Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research[1].
Product Specifications
CAS Number
1214645-87-0
UNSPSC
12352005
Target
Adrenergic Receptor; Arrestin
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
CCN1CCN(C(C(O)=O)C2=CNC3=C2C=CC(NC(C4C(CC=CC4)C(O)=O)=O)=C3)CC1
Molecular Formula
C24H30N4O5
Molecular Weight
454.52
References & Citations
[1]Kurt H, et al. A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor. Commun Chem. 2025 Jul 1;8 (1) :194.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Arrestin-3/β-Arrestin 2; β adrenergic receptor
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