XIAP-CASP7 PPI-IN-1
Xiap-casp7 PPI-IN-1 is a reversible XIAP: CASP7 inhibitor with specifically disrupting the interaction between XIAP and CASP7. XIAP-CASP7 PPI-IN-1 selectively induce MCF-7 and other caspase-3 down-regulation (CASP3/DR) triple-negative breast cancer cell apoptosis. XIAP-CASP7 PPI-IN-1 overcomes chemoresistance via down-regulating β-catenin and its associated ABC transporters in Paclitaxel -resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; β-catenin
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC2=C(C3=C(N(N=C3C)C4=CC=CC=C4)N=C2C5=CC=C(O)C=C5)C=C1OC
Molecular Formula
C25H21N3O3
Molecular Weight
411.45
References & Citations
[1]Do CT, et al. Targeting DDR2 for Treating Pancreatic Cancer. Mol Cancer Ther. 2025 Jun 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Caspase 9
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
genesig Easy AnimalFINDER Detection Kit for Ovis aries
KLHL25 (ENC2, Ectoderm-neural Cortex Protein 2, Kelch-like Protein 25, ENC-2, FLJ12587, FLJ45015) (AP)
KLHL25 (ENC2, Ectoderm-neural Cortex Protein 2, Kelch-like Protein 25, ENC-2, FLJ12587, FLJ45015) (AP)
