DiABZI-a1
DiABZI-a1 is a orthosteric STING agonist with EC50 of 117 nM for IFNβ in human PBMCs. diABZI-a1 can be used for monogenic autoinflammatory disease like SAVI disease research[1].
Product Specifications
CAS Number
2138299-43-9
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
CCN1N=C(C=C1C(NC2=NC3=C(N2C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OC)=CC(C(N)=O)=C6)C(OC)=CC(C(N)=O)=C3)=O)C
Molecular Formula
C36H40N12O6
Molecular Weight
736.78
References & Citations
[1]Xie T, et al. Orthosteric STING inhibition elucidates molecular correction of SAVI STING. Nat Commun. 2025 Jul 1;16 (1) :5695.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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