Jun6504
Jun6504 is an enterovirus 2C inhibitor. Jun6504 shows potent and broad-spectrum antiviral activity against multiple strains of EV-D68 (EC50 = 250 nM), EV-A71 (EC50 = 502.4 nM), and CVB3 (EC50 = 1049 nM) . Jun6504 improves paralysis score and weight gain in a neonatal mouse model of EV-D68 infection. Jun6504 reduces viral titers in the spinal cord and the infected quadriceps muscle. Jun6504 can be used for EV-D68 antiviral research[1].
Product Specifications
UNSPSC
12352005
Target
Enterovirus
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(NCC1(CNC1)C)C2=C(C=NN3C(C)C)C3=NC(C4CC4)=C2
Molecular Formula
C18H25N5O
Molecular Weight
327.42
References & Citations
[1]Li K, et al. A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis. Nat Commun. 2025 Jul 1;16 (1) :5987.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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