TPAPyN
TPAPyN is a nitroreductase (NTR) -responsive type I photosensitizer. TPAPyN facilitates the imaging of hypoxic cancer cells and image-guided photodynamic therapy (PDT) . TPAPyN does not emit fluorescence in the aqueous environment, but restores when NTR cleaves the nitrofuran quencher with aggregation-induced emission. TPAPyN can be used as a fluorescent probe for specific imaging of hypoxic cancer[1].
Product Specifications
UNSPSC
12352005
Target
Photosensitizer
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
COC1=CC=C(N(C2=CC=C(OC)C=C2)C3=CC=C(/C=C/C4=CC=[N+](CC5=CC=C([N+]([O-])=O)O5)C=C4)C=C3)C=C1.[Br-]
Molecular Formula
C32H28BrN3O5
Molecular Weight
614.49
References & Citations
[1]Lam KWK, et al. A Nitroreductase-Responsive Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Precise Hypoxic Cancer Theranostics. ACS Nano. 2025 Jul 15;19 (27) :24701-24712.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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MBS6286726-01 0.2 mL
CLEC7A, NT (CLEC7A, BGR, CLECSF12, DECTIN1, C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1) (FITC)
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MBS6286726-02 5x 0.2 mL
CLEC7A, NT (CLEC7A, BGR, CLECSF12, DECTIN1, C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1) (FITC)
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