KRASG12D-IN-6
KRASG12D-IN-6 is a PROTAC target protein ligand that can be used to synthesize CH091138 (HY-175025) . CH091138 is a potent and selective KRASG12D PROTAC degrader with anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
OC1=CC(C=CC=C2C#C)=C2C(C3=C(F)C(N=C(OC[C@@H]4CCCN4)N=C5N6C[C@H]7N[C@H](CC7)C6)=C5C=N3)=C1
Molecular Formula
C30H29FN6O2
Molecular Weight
524.59
References & Citations
[1]Jeon E, et al. KRASG12D selective VHL-PROTAC with sparing KRASWT and other KRAS mutants. Eur J Med Chem. 2025 Jul 5;297:117928.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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