Chloroguanabenz (acetate)
Chloroguanabenz (acetate) is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz. Chloroguanabenz (acetate) can inhibit the formation of prion in yeast and mammalian in vitro assays. Chloroguanabenz (acetate) can reduce the levels of truncated Huntingtin derivative Htt48 in HEK293T cells. Chloroguanabenz (acetate) can be studied in research on Huntington’s disease[1][2].
Product Specifications
CAS Number
[2242615-97-8]
Product Name Alternative
GAh (acetate)
UNSPSC
12352101
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Infection; Neurological Disease
Smiles
ClC1=C(C(Cl)=CC=C1Cl)/C=N/NC(N)=N.OC(C)=O
Molecular Formula
C10H11Cl3N4O2
Molecular Weight
325.58
References & Citations
[1]Anne Bertolotti and Marc Blondel, Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases. US7932422B2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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