PtdIns- (4,5) -P2-biotin (trisodium)
PtdIns- (4,5) -P2-biotin trisodium is a Biotin-labeled PtdIns- (4,5) -P2 analog. PtdIns- (4,5) -P2-biotin trisodium is an affinity probe of PI3Kγ. PI3Kγ can catalyse the phosphorylation of PtdIns- (4,5) -P2 at the 3′-OH group, giving rise to the second messenger PtdIns (3,4,5) -P3[1].
Product Specifications
UNSPSC
12352005
Target
Drug Derivative; PI3K
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Others
Smiles
O[C@H]1[C@@H]([C@H]([C@@H]([C@@H]([C@@H]1OP(OC[C@@H](OC(CCCCCCC)=O)COC(CCCCCCCNC(CCCC[C@H]2SC[C@@]([H])([C@@]2(N(C3=O)[H])[H])N3[H])=O)=O)(O[Na])=O)O)O)OP(O)(O[Na])=O)OP(O)(O[Na])=O
Molecular Formula
C35H61N3Na3O21P3S
Molecular Weight
1053.82
References & Citations
[1]Rückle T, et al. PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov. 2006 Nov;5 (11) :903-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ
Curated Selection
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