8-Br-cADPR (sodium salt)

8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) sodium salt, a cyclic adenosine diphosphate (ADP) -ribose (cADPR) antagonist, is a TRPM2 ion channel antagonist. 8-Br-cADPR sodium salt reduces renal damage and the expression of caspase-3 and TRPM2[1].

Product Specifications

Product Name Alternative

8-Bromo-Cyclic ADP-Ribose (sodium salt)

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN([C@H]4[C@H](O)[C@H](O)[C@@H](COP(O5)(O[Na])=O)O4)C3=N)O[C@@H]1COP5(O[Na])=O

Molecular Formula

C15H18BrN5Na2O13P2

Molecular Weight

664.16

References & Citations

[1]Eraslan E, et al. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol. 2019 Apr;234 (4) :4572-4581.