8-Br-cADPR (sodium salt)
8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) sodium salt, a cyclic adenosine diphosphate (ADP) -ribose (cADPR) antagonist, is a TRPM2 ion channel antagonist. 8-Br-cADPR sodium salt reduces renal damage and the expression of caspase-3 and TRPM2[1].
Product Specifications
Product Name Alternative
8-Bromo-Cyclic ADP-Ribose (sodium salt)
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN([C@H]4[C@H](O)[C@H](O)[C@@H](COP(O5)(O[Na])=O)O4)C3=N)O[C@@H]1COP5(O[Na])=O
Molecular Formula
C15H18BrN5Na2O13P2
Molecular Weight
664.16
References & Citations
[1]Eraslan E, et al. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol. 2019 Apr;234 (4) :4572-4581.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175081/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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