IP receptor antagonist 1
CAY10449 is an I prostanoid receptor antagonist. CAY10449 can reverse iloprost-induced TEER reduction. CAY10449 can also reverse the effect of ONO-1301 in mouse model. CAY10449 can be studied in research on athsma and allergic airway inflammation[1][2][3].
Product Specifications
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(OC1=CC=C(C(C2=CC=C(NC3=NCCN3)C=C2)=O)C=C1)C
Molecular Formula
C19H21N3O2
Molecular Weight
323.39
References & Citations
[1]Tasha R Womac, et al., Prostacyclin as a Negative Regulator of Angiogenesis in the Neurovasculature. |[2]Hayashi, M., et al., (2010) . A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 40 (2), 317-326. |[3]Kuo, C. H., et al., (2010) . Prostaglandin I (2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells. Inflammation, 33 (5), 334-343.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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