D-myo-Inositol-2,4,5-triphosphate (sodium salt)

D-myo-Inositol-2,4,5-triphosphate (Ins (2,4,5) P3) (sodium salt) is a second messenger produced in cells by phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can open calcium channels and increase intracellular calcium upon binding to its receptors on the endoplasmic reticulum. D-myo-Inositol-2,4,5-triphosphate (sodium salt) also acts as a partial agonist at rat hepatic IP3 receptors. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can be studied in research on calcium ions signaling pathway[1][2][3][4].

Product Specifications

Product Name Alternative

Ins (2,4,5) P3 (sodium salt) ; 2,4,5-IP3 (sodium salt)

UNSPSC

12352211

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1OP(O)(O[Na])=O)O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)O

Molecular Formula

C6H12Na3O15P3

Molecular Weight

486.04

References & Citations

[1]Streb, H., et al., (1983) . Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature, 306 (5938), 67–69.|[2]Yoshida, Y., & Imai, S. (1997) . Structure and function of inositol 1,4,5-trisphosphate receptor. Japanese journal of pharmacology, 74 (2), 125–137. |[3]Exton J. H. (1996) . Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annual review of pharmacology and toxicology, 36, 481–509. |[4]Marchant, J. S., et al., (1997) . Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins (2,4,5) P3 is a partial agonist at hepatic InsP3 receptors. The Biochemical journal, 321 (Pt 3) (Pt 3), 573–576.