Enpp-1-IN-26

Enpp-1-IN-26 (Compound 4e) is an ENPP1 inhibitor with an IC50 of 0.188 μM. Enpp-1-IN-26 enhances IFN-β expression in vivo by preventing ENPP1 from hydrolyzing cGAMP. Enpp-1-IN-26 can be used in the research of metastatic breast cancer[1].

Product Specifications

CAS Number

[2848714-91-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

FC1=CC2=C(C(NC(CSC3=NC4=NC(OC)=CC=C4N3)=N2)=O)C=C1

Molecular Formula

C16H12FN5O2S

Molecular Weight

357.36

References & Citations

[1]Wang X, et al. Development of Novel Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Tumor Immunotherapy. Int J Mol Sci. 2022 Jun 26;23 (13) :7104.