PROTAC FLT-3 degrader 5
PROTAC FLT-3 degrader 5 is a FLT3 PROTAC degrader (DC50 = 1.2 nM) . PROTAC FLT-3 degrader 5 functions as a molecular glue to degrade cereblon substrates GSPT1 and IKZF1/3. PROTAC FLT-3 degrader 5 exhibits antiproliferative activity against drug-resistant acute myeloid leukemia (AML) cells and is potentially useful in AML research. (Pink: FLT3/GSPT1/IKZF1/3 ligand: (HY-169374) ; Blue: Thalidomide: (HY-14658) ; Black: linker; Thalidomide + linker: (HY-W1123823) ) [1].
Product Specifications
UNSPSC
12352005
Target
FLT3; IKZF Family; Molecular Glues; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC(N(C4)CCC4CN5CCN(C(CC6)CCN6C(C=C7)=C(OC)C=C7NC8=NC(NC9CCOCC9)=C(CC)N=C8C(N)=O)CC5)=C3)=O
Molecular Formula
C46H59N11O7
Molecular Weight
878.03
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; IKZF1; IKZF3
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