PROTAC FLT-3 degrader 5

PROTAC FLT-3 degrader 5 is a FLT3 PROTAC degrader (DC50 = 1.2 nM) . PROTAC FLT-3 degrader 5 functions as a molecular glue to degrade cereblon substrates GSPT1 and IKZF1/3. PROTAC FLT-3 degrader 5 exhibits antiproliferative activity against drug-resistant acute myeloid leukemia (AML) cells and is potentially useful in AML research. (Pink: FLT3/GSPT1/IKZF1/3 ligand: (HY-169374) ; Blue: Thalidomide: (HY-14658) ; Black: linker; Thalidomide + linker: (HY-W1123823) ) [1].

Product Specifications

UNSPSC

12352005

Target

FLT3; IKZF Family; Molecular Glues; PROTACs

Related Pathways

Immunology/Inflammation; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC(N(C4)CCC4CN5CCN(C(CC6)CCN6C(C=C7)=C(OC)C=C7NC8=NC(NC9CCOCC9)=C(CC)N=C8C(N)=O)CC5)=C3)=O

Molecular Formula

C46H59N11O7

Molecular Weight

878.03

References & Citations

[1]Yang Y, et al. Discovery of degrader for FLT3, GSPT1 and IKZF1/3 proteins merging PROTAC and molecular glue targeting FLT3-ITD mutant acute myeloid leukemia. Eur J Med Chem. 2025 Oct 15;296:117893.