DNH28
DNH28 is a potent NF-κB and MAPK inhibitor with an IC50 of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and Cleaved-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; NF-κB; p38 MAPK
Related Pathways
Apoptosis; MAPK/ERK Pathway; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CCN1CCN(C2=CC(CC/C(C3=O)=C\C4=CC=C(F)C(F)=C4F)=C3C=C2)CC1.Cl
Molecular Formula
C23H24ClF3N2O
Molecular Weight
436.90
References & Citations
[1]Yu L, et al. Novel 3,4-dihydronaphthalen-1 (2H) -one derivatives promote apoptosis and inhibit migration of hepatocellularcarcinoma cells via inhibition of NF-κB and MAPK signaling pathways. Eur J Med Chem. 2025 Oct 15;296:117898.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; NF-κB
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