YTHu78

YTHu78 is a KDM5B PROTAC-type degrader. YTHu78 induces KDM5B degradation via the ubiquitin-proteasome system and triggers apoptosis in MV-4-11 and MM.1S cell lines. YTHu78 exhibits significant antiproliferative activity against a variety of hematological cancer cell lines and can be used to study hematological cancers. (Pink: KDM5B ligand: (HY-116761) ; Blue: Thalidomide: (HY-14658), Black + Pink: KDM5B ligand + linker: (HY-175145) ) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; Histone Demethylase; PARP; PROTACs

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1NC(OC2=CN(CC3=CC=C(CCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)N=C2)=NC7=CN=CC=C71

Molecular Formula

C33H28N8O6

Molecular Weight

632.63

References & Citations

[1]Liu X, et al. Design, synthesis, and biological evaluation of KDM5B degraders against hematologic malignancy cells. Eur J Med Chem. 2025 Oct 15;296:117883