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HK-2-IN-1

HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Hexokinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Purity

99.88

Smiles

ClC(C=C1Cl)=CC=C1CN(C2=CC(F)=CC=C23)N=C3C4=NC(CC5=CC=CC=C5)=NN4

Molecular Formula

C23H16Cl2FN5

Molecular Weight

452.31

References & Citations

[1]Şavluğ İpek Ӧ, et al. Anti-cancer efficacy of novel lonidamine derivatives: Design, synthesis, in vitro, in vivo, and computational studies targeting hexokinase-2. Eur J Med Chem. 2025 Oct 15;296:117890.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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