ATF3-IN-1

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].

Product Specifications

CAS Number

[2952703-90-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Purity

96.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O

Molecular Formula

C24H37NO7

Molecular Weight

451.55

References & Citations

[1]Kong X, et al. Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway. Eur J Med Chem. 2025 Oct 15;296:117873.