GRL-07524
GRL-07524 (Compound 4e) is a potent inhibitor of HIV-1 protease (Ki = 0.22 nM) . GRL-07524 contains oxaspirocyclic carbamates as the P2 ligands. GRL-07524 exhibits good antiviral activity with an EC50 = 210 nM. GRL-07524 binds to the HIV-1 PR active site in one of the four symmetry independent molecules along with key catalytic residues[1].
Product Specifications
UNSPSC
12352005
Target
HIV Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=CC=C(C=C1)S(=O)(N(CC(C)C)C[C@@H](O)[C@@H](NC(O[C@H]2CCC[C@@]23C[C@@H](C4=C(C=CC=C4)OC)OCC3)=O)CC5=CC=CC=C5)=O
Molecular Formula
C38H50N2O8S
Molecular Weight
694.88
References & Citations
[1]Ghosh, A. K., et al., (2025) . Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands. European journal of medicinal chemistry, 297, 117880. Advance online publication.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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