ALG-097558

ALG-097558 is an orally active 3CLpro inhibitor. ALG-097558 demonstrates pan-coronavirus activity against various SARS-CoV-2 variants as well as other human coronaviruses (HCoVs) such as SARS-CoV-1, α-HCoV 229E, and β-HCoV OC43. ALG-097558 demonstrates potent inhibition with IC50s of 2 nM (SARS-CoV-2 3CLpro) and 6 nM (229E 3CLpro) . ALG-097558 demonstrates antiviral activity in the SARS-CoV-2 hamster infection model. ALG-097558 can be used for the study of viral infections[1].

Product Specifications

CAS Number

[2892287-29-3]

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[H][C@@]12[C@@H]3C=C[C@H]([C@@]1([C@H](N(C2)C([C@H](C(C)(C)C)NC(C(F)(Cl)F)=O)=O)C(N[C@@H](C[C@@H]4CCNC4=O)C#N)=O)[H])C3

Molecular Formula

C25H32ClF2N5O4

Molecular Weight

540.00

References & Citations

[1]Bardiot D, et al. Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor. J Med Chem. 2025 Jul 10;68 (13) :13436-13454.