VEGFR-2-IN-71

VEGFR-2-IN-71 is a dual VEGFR2/tubulin inhibitor. VEGFR-2-IN-71 inhibits tumor cell proliferation and induces apoptosis and cell cycle arrest. VEGFR-2-IN-71 inhibits angiogenesis in the chick chorioallantoic membrane (CAM) model. VEGFR-2-IN-71 inhibits tumor growth in the HGC-27 xenograft model by inhibiting VEGFR2 and tubulin. VEGFR-2-IN-71 has low oral bioavailability in rats. VEGFR-2-IN-71 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; VEGFR

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

COC1=C(OC)C(OC)=C(C(C=C(C2=CC=C(NC(NC3=CC=C(F)C(C(F)(F)F)=C3)=O)C=C2)O4)=O)C4=C1

Molecular Formula

C26H20F4N2O6

Molecular Weight

532.44

References & Citations

[1]He X, et al. Discovery of novel flavonoid derivatives targeting VEGFR2 and tubulin with potent anticancer efficacy. Bioorg Chem. 2025 Jun 30;163:108713.