Survivin-IN-2
Survivin-IN-2 is a survivin inhibitor. Survivin-IN-2 shows cytotoxicity in cells with IC50s of 0.53 μM (C4-2 cells) and 1.06 μM (PC-3 cells) . Survivin-IN-2 effectively suppresses xenograft tumor growth without apparent toxicity and eliminates survivin in the tumors. Survivin-IN-2 can be used for the study of prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
Survivin
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(F)(F)C(C=C1)=CC=C1NC2=NC3=CC=CC=C3N=C2NC4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C22H14F6N4
Molecular Weight
448.36
References & Citations
[1]Cui Q, et al. Design, synthesis, and evaluation of quinoxaline-based survivin inhibitors for castration-resistant prostate cancer. Bioorg Chem. 2025 Jul 1;163:108714
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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