NADH-IN-3

NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb) . NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329) ) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) [1].

Product Specifications

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection; Metabolic Disease

Smiles

CC(C1=CC2=C(N=C(S2)SCC(NC3CC3)=O)C=C1)C

Molecular Formula

C15H18N2OS2

Molecular Weight

306.45

References & Citations

[1]Saha P, et al. Targeting drug-resistant tuberculosis: Thioacetamide-substituted benzothiazoles as bactericidal agents inhibiting type II NADH dehydrogenase. Bioorg Chem. 2025 Jul 3;163:108718.