LGT-1
LGT-1 is a PD-L1 ligand. LGT-1 labeled with 18F has an excellent specific uptake in B16-F10 tumor cells, and shows a high tumor uptake but a low liver uptake with good stability in B16-F10 tumor-bearing mice model. LGT-1 can be used as a radiotracer for PET imaging of PD-L1 expression in tumors[1].
Product Specifications
UNSPSC
12352005
Target
Biochemical Assay Reagents; PD-1/PD-L1
Related Pathways
Immunology/Inflammation; Others
Field of Research
Cancer
Smiles
FCCOCCOCCOCCN1C=C(N=N1)COC2=CC(OCC3=C(C(C4=CC5=C(OCCO5)C=C4)=CC=C3)C)=C(C=C2CNC(CO)(CO)CO)Cl
Molecular Formula
C38H48ClFN4O10
Molecular Weight
775.26
References & Citations
[1]Zhang N, et al. Development and evaluation of biphenyl-based small-molecule radiotracers for PET imaging of PD-L1 in tumor. Bioorg Med Chem Lett. 2025 Jul 1;122:130187.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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