MRC-G-001

MRC-G-001 is a Genipin (HY-17389) derivative with an IC50 of 117 μM against A549 cancer cells. MRC-G-001 inhibits the phosphorylation of EGFR, JAK1, and STAT3, and modulates epithelial-mesenchymal transition (EMT) -related protein expression, thereby attenuating cell migration and invasion. MRC-G-001 induces cell cycle arrest and cell apoptosis. MRC-G-001 can be used for the study of cancers such as non-small-cell lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; JAK; STAT

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

[H][C@]12CC=C([C@]1([C@@H](OC=C2C(OC)=O)OC(C)C)[H])CNCC3=CC=CC=C3

Molecular Formula

C21H27NO4

Molecular Weight

357.44

References & Citations

[1]Kim DH, et al. Genipin derivative induced the apoptosis and inhibited the invasion and migration of A549 cancer cells via regulation of EGFR/JAK1/STAT3 signaling. Bioorg Med Chem Lett. 2025 Jun 29;128:130320.