PBD dimer-4
PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine to treat several different cancer types[1].
Product Specifications
CAS Number
1821339-88-1
UNSPSC
12352005
Target
ADC Payload; DNA Alkylator/Crosslinker
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
[H][C@]12C=NC3=CC(OC)=C(C=C3C(N1CC[C@@H]2OCCCO[C@H]4CCN5C(C6=CC(OC)=C(C=C6N=C[C@]45[H])OC)=O)=O)OC
Molecular Formula
C31H36N4O8
Molecular Weight
592.64
References & Citations
[1]Procopiou G, et al. Synthesis of novel pyrrolobenzodiazepine (PBD) C1-substituted monomers and dimers with DNA-binding activity and cytotoxicity. Bioorg Med Chem Lett. 2025 Apr 15;119:130095.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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