HV1-IN-2
HV1-IN-2 (Compound 14c) is a human voltage-gated proton channel (HV1) inhibitor with an IC50 of 2.14 μM. HV1-IN-2 has a potent anticancer activity with significant antiproliferative effects against THP-1 and MCF-7 cells. HV1-IN-2 can be used for cancers research, such as colorectal tumours, leukaemia, and breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Concentration
10mM
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=CC=C(OCC3=CC=CC(C(F)(F)F)=C3)C=C2)N1
Molecular Formula
C17H14F3N3O
Molecular Weight
333.31
References & Citations
[1]Piga M, et al. Targeting voltage-gated proton channel HV1: Optimised 5-phenyl-2-aminoimidazoles with anticancer potential. Eur J Med Chem. 2025 Jul 7;297:117936.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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