HV1-IN-2

HV1-IN-2 (Compound 14c) is a human voltage-gated proton channel (HV1) inhibitor with an IC50 of 2.14 μM. HV1-IN-2 has a potent anticancer activity with significant antiproliferative effects against THP-1 and MCF-7 cells. HV1-IN-2 can be used for cancers research, such as colorectal tumours, leukaemia, and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Concentration

10mM

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=CC=C(OCC3=CC=CC(C(F)(F)F)=C3)C=C2)N1

Molecular Formula

C17H14F3N3O

Molecular Weight

333.31

References & Citations

[1]Piga M, et al. Targeting voltage-gated proton channel HV1: Optimised 5-phenyl-2-aminoimidazoles with anticancer potential. Eur J Med Chem. 2025 Jul 7;297:117936.