PI3Kδ-IN-24
PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM) . PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL) [1].
Product Specifications
CAS Number
3051829-20-7
UNSPSC
12352005
Target
Akt; Apoptosis; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
COC1=C(C=C(C2=CC=C3N=CN=C(C3=N2)N[C@@H](C)C(N4CCN(CC4)C)=O)C=N1)C(OC5=CC=CC=C5)=O
Molecular Formula
C28H29N7O4
Molecular Weight
527.57
References & Citations
[1]Yuan B, Ma M, Wu Y, Liu J, Chen M, Lai Y, Zhang SQ, Xin M. Discovery of novel covalent PI3Kδ inhibitors bearing alaninamide moiety by lysine-targeted covalent strategy. Eur J Med Chem. 2025 Jul 7;297:117948.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kγ; PI3Kδ
Frequently Asked Questions
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