PI3Kδ-IN-24

PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM) . PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL) [1].

Product Specifications

CAS Number

[3051829-20-7]

UNSPSC

12352005

Target

Akt; Apoptosis; PI3K

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

COC1=C(C=C(C2=CC=C3N=CN=C(C3=N2)N[C@@H](C)C(N4CCN(CC4)C)=O)C=N1)C(OC5=CC=CC=C5)=O

Molecular Formula

C28H29N7O4

Molecular Weight

527.57

References & Citations

[1]Yuan B, Ma M, Wu Y, Liu J, Chen M, Lai Y, Zhang SQ, Xin M. Discovery of novel covalent PI3Kδ inhibitors bearing alaninamide moiety by lysine-targeted covalent strategy. Eur J Med Chem. 2025 Jul 7;297:117948.