PFI-7-O-C4-piperazin
PFI-7-O-C4-piperazin is a E3 ligase ligand-linker conjugate that can be used for synthesis of PROTACs, such as NEP162 (HY-174996) . The E3 ligase ligand (PFI-7) of NEP162 is a highly selective antagonist of GID4 (KD = 0.22 μM) . NEP162 is a BRD4 PROTAC degrader with anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N[C@@H]1CC[C@H](C2=NC(C=CC(OCCCN3CCNCC3)=C4)=C4N2)CC1)CNCC(N5)=CC6=C5C=CC=C6
Molecular Formula
C31H41N7O2
Molecular Weight
543.70
References & Citations
[1]Li Y, et al. Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation. Nat Struct Mol Biol. 2025 Apr 28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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