PFI-7-O-C4-piperazin

PFI-7-O-C4-piperazin is a E3 ligase ligand-linker conjugate that can be used for synthesis of PROTACs, such as NEP162 (HY-174996) . The E3 ligase ligand (PFI-7) of NEP162 is a highly selective antagonist of GID4 (KD = 0.22 μM) . NEP162 is a BRD4 PROTAC degrader with anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@@H]1CC[C@H](C2=NC(C=CC(OCCCN3CCNCC3)=C4)=C4N2)CC1)CNCC(N5)=CC6=C5C=CC=C6

Molecular Formula

C31H41N7O2

Molecular Weight

543.70

References & Citations

[1]Li Y, et al. Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation. Nat Struct Mol Biol. 2025 Apr 28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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