JQ-1-Azidopropylamine

JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) [1].

Product Specifications

CAS Number

[2915642-70-3]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.5700

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCN=[N+]=[N-])=O

Molecular Formula

C22H23ClN8OS

Molecular Weight

482.99

References & Citations

[1]Du J, et al. Azoacetylene Electrophiles for Proteome-wide Ligand and Target Discovery: Supporting Targeted Protein Degradation. J Med Chem. 2025 Jul 10;68 (13) :13516-13531.