JQ-1-Azidopropylamine
JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) [1].
Product Specifications
CAS Number
[2915642-70-3]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.5700
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCN=[N+]=[N-])=O
Molecular Formula
C22H23ClN8OS
Molecular Weight
482.99
References & Citations
[1]Du J, et al. Azoacetylene Electrophiles for Proteome-wide Ligand and Target Discovery: Supporting Targeted Protein Degradation. J Med Chem. 2025 Jul 10;68 (13) :13516-13531.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
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