Apoptosis inducer 39

Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]

Molecular Formula

C16H10BrF3N4O3

Molecular Weight

443.17

References & Citations

[1]Yang M, et al. Synthesis of quinazoline derivatives and their in vitro inhibition activity against MDA-MB-231 cells and A549 cells. Bioorg Med Chem Lett. 2025 Nov 1;127:130308.