Apoptosis inducer 39
Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]
Molecular Formula
C16H10BrF3N4O3
Molecular Weight
443.17
References & Citations
[1]Yang M, et al. Synthesis of quinazoline derivatives and their in vitro inhibition activity against MDA-MB-231 cells and A549 cells. Bioorg Med Chem Lett. 2025 Nov 1;127:130308.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2
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