ATM-IN-2
ATM-IN-2 is a selective and orally active ATM inhibitor with an IC50 of 4 nM. ATM-IN-2 exhibits excellent kinase selectivity (>700-fold over PIKK family members) . ATM-IN-2 exerts its anti-tumor effect by inhibiting ATM phosphorylation and the downstream signaling pathways (p53, H2AX), and promotes cell apoptosis. ATM-IN-2 can be used for the study of chemosensitizer candidate such as colon cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ATM/ATR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(S(=O)(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C4=CC(C5=CC=CC=C5)=NO4)=O)C
Molecular Formula
C25H21N3O3S
Molecular Weight
443.52
References & Citations
[1]Guo T, et al. Discovery of 1H-Pyrrolo[2,3-b] pyridine Derivatives as Highly Selective, and Orally Available ATM Inhibitors with Potent In Vivo Antitumor Activity. J Med Chem. 2025 Jul 10;68 (13) :13907-13934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
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