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MGluR1 activator-1

MGluR1 activator-1 is a stable Vitamin K analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s[1].

Product Specifications

UNSPSC

12352005

Target

MGluR; Steroid Sulfatase

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(/C(C)=C/C=C/C(C)=C/CC/C(C)=C/CC1=C(C(C2=C(C1=O)C=CC=C2)=O)C)OC

Molecular Formula

C27H30O4

Molecular Weight

418.52

References & Citations

[1]Hirota Y, et al. A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation. ACS Chem Neurosci. 2025 Jul 3.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR1

Frequently Asked Questions

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