CGRP antagonist 7

CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with an IC50 of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine[1].

Product Specifications

CAS Number

[2173508-07-9]

UNSPSC

12352005

Target

CGRP Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CC1=NNC(C(CC2=CC=C(C=C2C)C(NCC(N3[C@@H](CC[C@@H]3C(C)(C#N)C)C4=CC(F)=CC=C4)=O)=O)=C1)=O

Molecular Formula

C30H32FN5O3

Molecular Weight

529.61

References & Citations

[1]Morita N, et al. Fragment-Based Discovery of an Oral Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine. J Med Chem. 2025 Jul 24;68 (14) :14919-14944.