Anti-MRSA agent 32
Anti-MRSA agent 32 (Compound 26) is an orally active and selective SaClpP (Staphylococcus aureus ClpP protease) activator with an EC50 value of 0.98 μM. Anti-MRSA agent 32 activates SaClpP to abnormally degrade bacterial proteins, inhibiting the proliferation of Staphylococcus aureus. Anti-MRSA agent 32 promotes wound healing in a murine skin infection model. Anti-MRSA agent 32 is promising for research of infectious diseases such as methicillin-resistant Staphylococcus aureus (MRSA) infections[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CCOC[C@H]1CC2=C(C(N(C3=NCCN32)CC4=CC=C(C=C4)Cl)=O)CN1CC5=CC(F)=CC=C5
Molecular Formula
C26H28ClFN4O2
Molecular Weight
482.98
References & Citations
[1]Luo J, et al. Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents. J Med Chem. 2025 Jul 24;68 (14) :14555-14568.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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