VCP/p97 IN-3
VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM (N660K) and 19 nM (V474A/D649A) . VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma[1].
Product Specifications
CAS Number
[3098437-66-9]
UNSPSC
12352005
Target
Caspase; p62; p97
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(OCC#CC1=CC(F)=C(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CC=CN=C4)C=C1F)NC(C5)CC65CN(C)C6
Molecular Formula
C31H32F2N6O3S
Molecular Weight
606.69
References & Citations
[1]Green N, et al. Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors. J Med Chem. 2025 Jul 24;68 (14) :14465-14494.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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