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PRMT5-MTA-IN-6

PRMT5-MTA-IN-6 (Compound 31) is a selective MTA-cooperative PRMT5 inhibitor. PRMT5-MTA-IN-6 exhibits potent inhibitory activity against PRMT5MTA (IC50: 6.6 nM) . PRMT5-MTA-IN-6 selectively inhibits the growth of MTAP-deleted HCT-116 cells (IC50: 319 nM) . PRMT5-MTA-IN-6 can be used in the research of MTAP-deleted tumors[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NCC1=NNC(C2=CC=C(C=C21)C3=C4N(CCN4N=C3)CC5=CC(C6CC6)=CC7=C5OCC7)=O

Molecular Formula

C26H26N6O2

Molecular Weight

454.52

References & Citations

[1]Yang Y, et al. Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro‑1H‑imidazo[1,2‑b]pyrazole Scaffold. ACS Med Chem Lett. 2025 Jun 27;16 (7) :1313-1322.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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