Dac590
Dac590 is an orally active FTO inhibitor. Dac590 has a robust antiproliferative effect on AML cells, and induces apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival with no observed toxicity in acute myeloid leukemia (AML) xenograft mcie model, and shows a synergistic effect combined with Decitabine.
Product Specifications
CAS Number
3084407-00-8
UNSPSC
12352005
Target
Apoptosis; Fat Mass and Obesity-associated Protein (FTO)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
96.15
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1=CC(OC)=CC=C1NC2=C(C=C(C=C2Cl)C3=C(ON=C3C)C)F)=O
Molecular Formula
C19H16ClFN2O4
Molecular Weight
390.79
References & Citations
[1]Yang T, et al. Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy. J Med Chem. 2025 Jul 10;68 (13) :13714-13727.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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