Dac590

Dac590 is an orally active FTO inhibitor. Dac590 has a robust antiproliferative effect on AML cells, and induces apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival with no observed toxicity in acute myeloid leukemia (AML) xenograft mcie model, and shows a synergistic effect combined with Decitabine (HY-A0004) [1].

Product Specifications

CAS Number

[3084407-00-8]

UNSPSC

12352005

Target

Apoptosis; Fat Mass and Obesity-associated Protein (FTO)

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

96.15

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C1=CC(OC)=CC=C1NC2=C(C=C(C=C2Cl)C3=C(ON=C3C)C)F)=O

Molecular Formula

C19H16ClFN2O4

Molecular Weight

390.79

References & Citations

[1]Yang T, et al. Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy. J Med Chem. 2025 Jul 10;68 (13) :13714-13727.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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