FHND5032

FHND5032 is an orally active miR-124 inducer. FHND5032 significantly upregulates miR-124 expression in macrophages. FHND5032 disrupts inflammatory signaling, promotes macrophage reprogramming, and restores the epithelial barrier function by inhibiting the PIK3R2/PI3K/Akt axis. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mice. FHND5032 can be used for the study of ulcerative colitis[1].

Product Specifications

CAS Number

[3076057-63-8]

UNSPSC

12352005

Target

Akt; Bacterial; Interleukin Related; PI3K

Related Pathways

Anti-infection; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.49

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC(F)(OC1=CC=C(C=C1)NC2=NC3=CC(Cl)=CC=C3C=N2)F

Molecular Formula

C15H9ClF3N3O

Molecular Weight

339.70

References & Citations

[1]Wang T, et al. Novel Small-Molecule miR-124 Inducer Acts as "a Physiological Brake" of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis. J Med Chem. 2025 Jul 10;68 (13) :14114-14126.